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This Journal feature begins with a case vignette that includes a therapeutic recommendation. A discussion of the clinical problem and the mechanism of benefit of this form of therapy follows. Major clinical studies, the clinical use of this therapy, and potential adverse effects are reviewed. Relevant formal guidelines, if they exist, are presented. The article ends with the author's clinical recommendations.
A 45-year-old woman with a family history of postmenopausal breast cancer (in a maternal aunt) discovers a mass in the upper outer quadrant of her left breast. A mammogram reveals a spiculated density considered suspicious for cancer, and a
The Clinical Problem
Pathophysiology and Effect of Therapy
Clinical Evidence
Clinical Use
Adverse Effects
Areas of Uncertainty
Guidelines
Recommendations
Source Information
From the Department of Radiation Oncology, University of Texas M.D. Anderson Cancer Center, Houston.
Address reprint requests to Dr. Buchholz at the Department of Radiation Oncology, University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Blvd., Unit 97, Houston, TX 77030, or at tbuchhol@mdanderson.org.
Related Letters:
Radiation Therapy for Breast Cancer
Hamberger A. D., Roukos D. H., Buchholz T. A.
Extract |
Full Text |
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N Engl J Med 2009;
360:1362-1363, Mar 26, 2009.
Correspondence
This article has been cited by other articles:
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