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Hope and Suffering is an apt title for this dense, encyclopedic, and riveting book. It includes narratives from patients and their family members that detail the hope, suffering, and despair of the first two decades of cancer therapy, followed by the optimism and successes of the present. A scant 60 years have passed since the article by Sidney Farber et al. on temporary remissions in acute leukemia induced by aminopterin appeared in the Journal, but the battle against childhood cancers began more than a decade earlier in New York City at the Memorial Hospital for Cancer and Allied Diseases (which
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