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Editorial
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Volume 360:1139-1141 March 12, 2009 Number 11
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Melamine, Powdered Milk, and Nephrolithiasis in Chinese Infants
Craig B. Langman, M.D.

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 by Guan, N.
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Melamine, a synthetic nitrogenous product found in many industrial goods and even in fertilizer destined for use in growing crops for human consumption, was recently found to have been added to foods in China — including many different powdered infant formulas1 — to increase their measured, but not biologically available, protein content. Melamine is largely not degraded in humans, although several other compounds (ammeline, ammelide, and cyanuric acid) may become cocontaminants during the manufacturing process, and the main route of excretion after absorption from the gastrointestinal tract appears to be through the urine.2 The findings of acute kidney failure and . . . [Full Text of this Article]


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From the Feinberg School of Medicine, Northwestern University, Children's Memorial Hospital, Chicago.

This article (10.1056/NEJMe0900361) was published at NEJM.org on February 4, 2009.


Related Letters:

Ultrasonographic Evaluation of Melamine-Exposed Children in Hong Kong
Ho S. S. Y., Chu W. C. W., Wong K. T., Li C. K., Wong W., Ng P. C., Ahuja A. T.
Extract | Full Text | PDF  
N Engl J Med 2009; 360:1156-1157, Mar 12, 2009; published at www.nejm.org on Feb 4, 2009 (10.1056/NEJMc0809955). Correspondence

Melamine and Nephrolithiasis in Children in Taiwan
Wang I-J., Chen P.-C., Hwang K.-C.
Extract | Full Text | PDF  
N Engl J Med 2009; 360:1157-1158, Mar 12, 2009; published at www.nejm.org on Feb 4, 2009 (10.1056/NEJMc0810070). Correspondence

Melamine-Contaminated Powdered Formula and Urolithiasis
Ji K., Zhu S., Liu Z., Dharnidharka V. R., Hocking B., Guan N., Ding J., Langman C. B.
Extract | Full Text | PDF  
N Engl J Med 2009; 360:2675-2678, Jun 18, 2009. Correspondence

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