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Volume 360:1169-1171 March 19, 2009 Number 12
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An Uncertain Future for Cardiovascular Drug Development?
Alan M. Garber, M.D., Ph.D.

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The past year has been a challenging one for Pfizer, the world's largest pharmaceutical company. Its stock price has fallen as it has struggled to boost research productivity, going so far as to cut research jobs along with sales positions and spending $68 billion to purchase Wyeth in a bid to strengthen its product portfolio. Its troubles are not recent, and when it announced last September that it was getting out of the business of developing new drugs to prevent or treat cardiovascular disease,1 the news did not come as a complete surprise. The market for cardiovascular drugs was crowded, . . . [Full Text of this Article]


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Dr. Garber is a staff physician at the Veterans Affairs Palo Alto Health Care System and a professor of medicine, director of the Center for Primary Care and Outcomes Research, and director of the Center for Health Policy at Stanford University, Stanford, CA; he is also director of the Health Care Program and research associate at the National Bureau of Economic Research, Cambridge, MA.




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