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Correspondence
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Volume 360:1260-1262 March 19, 2009 Number 12
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Cytokine Induction after Laboratory-Acquired West Nile Virus Infection

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To the Editor: We report a case of laboratory-acquired West Nile virus infection after a needlestick injury in a 29-year-old, immunocompetent female scientist in South Africa, who was not infected with the human immunodeficiency virus. The needlestick exposed the scientist to cell-culture fluid containing the neuroinvasive-lineage 2 West Nile virus strain SPU93/01 at a tissue culture infectious dose (the concentration that has a cytopathic effect in 50% of cultures inoculated) of 50 copies per cubic millimeter. The strain had previously been isolated from a patient with nonfatal encephalitis in South Africa.1,2 Blood specimens obtained on the day of infection (upon . . . [Full Text of this Article]




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