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Previous Volume 360:1461-1463 April 2, 2009 Number 14 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: In their report on the Colorectal Adenoma/Carcinoma Prevention Programme 2 (CAPP2) study, Burn et al. (Dec. 11 issue)¹ conclude that the use of aspirin, resistant starch, or both had no effect in reducing the risk of adenoma and carcinoma among carriers of the Lynch syndrome, on the basis of Cox proportional-hazards models adjusted for age and sex. However, the effect of the genotype-by-environment interaction on the risk of colorectal neoplasia was neglected.

According to two studies,^2,3 germline mutations or polymorphisms in DNA mismatch-repair genes may be associated with a significant difference in the risk of colorectal cancer. . . . [Full Text of this Article]

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