Obesity has reached epidemic proportions, and complicationsrelated to obesity contribute substantially to health care costsand mortality. Since the accumulation of fat is the net resultof a prolonged state of imbalance between energy intake andenergy expenditure, one would think that an ideal fat mass inobese persons could be achieved relatively simply by eitherdecreasing food intake or increasing energy expenditure, ultimatelycausing a sustained negative energy balance. Unfortunately,this is not so easy to achieve, because evolutionary pressurehas rewarded those individuals and species able to store sufficientenergy to survive famines; also, the unrestricted availability. . . [Full Text of this Article]
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From the Clinical Endocrinology Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD.
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