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Correspondence
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Volume 360:1574 April 9, 2009 Number 15
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Postpartum Venous Thromboembolism

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by Zalts, R.
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To the Editor: In their Image in Clinical Medicine, Zalts and Hayek (Dec. 18 issue)1 describe a woman with postpartum venous thromboembolism. The patient was found to be heterozygous for a mutation in the gene encoding for 5,10-methylenetetrahydrofolate reductase (MTHFR). The authors suggest that the mutation was most likely the source of her susceptibility to hypercoagulation. However, a recent, large-scale, prospective study involving 66,140 participants did not show an association between a homozygous or heterozygous MTHFR genotype and the risk of venous thromboembolism.2 The odds ratio for the development of venous thromboembolism was 1.01 for the heterozygous (C677CT) or homozygous . . . [Full Text of this Article]


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