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Previous Volume 360:1671-1672 April 16, 2009 Number 16 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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In early December 2008, the Food and Drug Administration (FDA) held an unusual joint meeting of the Pulmonary–Allergy Drugs Advisory Committee, the Drug Safety and Risk Management Advisory Committee, and the Pediatric Advisory Committee to consider the safety of long-acting beta-agonists (LABAs). The meeting is described in detail in a Perspective in this issue of the Journal by Kramer,¹ who points out that decision making by the advisers and the FDA was hampered by the lack of data about the safety of LABAs.

LABAs, which are administered by inhalation, act by effecting prolonged stimulation of the β₂-adrenergic receptor. They . . . [Full Text of this Article]

Source Information

From the Department of Medicine, McMaster University, and the Firestone Institute of Respiratory Health, St. Joseph's Hospital (P.M.O) — both in Hamilton, ON, Canada.

Related Letters:

Long-Acting Beta-Agonists in Asthma
Agarwal A., Knobil K., Kramer J. M., O'Byrne P. M., Drazen J. M.
Extract | Full Text | PDF  
N Engl J Med 2009; 361:208-209, Jul 9, 2009. Correspondence

This article has been cited by other articles:

• Jaeschke, R., Nair, P., Thabane, L., Brozek, J. (2009). Potential Risks of Using LABAs with ICS Therapy. Am. J. Respir. Crit. Care Med. 180: 581-582 [Full Text]  
• Page, C. (2009). The {beta}2 receptor and airway hyper-responsiveness: are sensory nerves involved?. Thorax 64: 738-739 [Full Text]  
• Sears, M. R. (2009). Safety of Long-Acting {beta}-Agonists: Are New Data Really Required?. Chest 136: 604-607 [Abstract] [Full Text]  
• Agarwal, A., Knobil, K., Kramer, J. M., O'Byrne, P. M., Drazen, J. M. (2009). Long-acting beta-agonists in asthma.. NEJM 361: 208-209 [Full Text]  
• Jaeschke, R., Angus, D. C. (2009). Living With Uncertainty in the Intensive Care Unit: Should Patients With Sepsis Be Treated With Steroids?. JAMA 301: 2388-2390 [Full Text]