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Previous Volume 360:1678-1680 April 16, 2009 Number 16 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: In their review article, Chiang and Massagué (Dec. 25 issue)¹ give limited attention to the intravascular phase of the metastatic process. With the exception of cells in hematopoietic cancers, tumor cells do not typically circulate as independent entities (as depicted in Fig. 2 and 3 of the article). Rather, they are usually found in clumps, surrounded by a "cloak" of platelets and leukocytes.^2,3 This fact is of more than just academic interest. First, this is the phase in which the vast majority of potentially metastatic malignant cells perish, with the few surviving cells ultimately leading to the . . . [Full Text of this Article]

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