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Previous Volume 360:1696-1698 April 23, 2009 Number 17 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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The human genome has been cracked wide open in recent years and is spilling many of its secrets. More than 100 genomewide association studies have been conducted for scores of human diseases, identifying hundreds of polymorphisms that are widely seen to influence disease risk. After many years in which the study of complex human traits was mired in false claims and methodologic inconsistencies, genomics has brought not only comprehensive representation of common variation but also welcome rigor in the interpretation of statistical evidence. Researchers now know how to properly account for most of the multiple hypothesis testing involved in mining . . . [Full Text of this Article]

Source Information

Dr. Goldstein is director of the Center for Human Genome Variation, Institute for Genome Sciences and Policy, Duke University, Durham, NC.

This article (10.1056/NEJMp0806284) was published at NEJM.org on April 15, 2009.

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