Congestive heart failure is one of the leading causes of deathand complications in the developed world, and coronary arterydisease is the major cause of heart failure. Efforts to improveventricular function, symptoms, and clinical outcomes in patientswith heart failure have included neurohormonal inhibition withangiotensin-converting–enzyme inhibitors, angiotensin-receptorblockers, beta-blockers, and aldosterone antagonists, as wellas cardiac resynchronization therapy. All these therapies havebeen shown in randomized clinical trials to be beneficial.1However, none of them specifically address the coronary diseaseresponsible for ischemic cardiomyopathy and myocardial infarction.
Coronary-artery bypass grafting (CABG), which was first usedto ameliorate . . . [Full Text of this Article]
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From the Division of Cardiology, Drexel University College of Medicine, Philadelphia.
This article (10.1056/NEJMe0901815) was published at NEJM.org on March 29, 2009.
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