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Previous Volume 360:1787-1788 April 23, 2009 Number 17 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: Mullighan et al. (Jan. 29 issue)¹ report on the prognostic significance of IKZF1 alterations in pediatric patients with acute lymphoblastic leukemia (ALL). The authors also find that the gene-expression signature in patients with BCR-ABL–negative ALL, which is associated with a poor outcome (as predicted by IKZF1 alterations), is similar to the gene-expression profile in patients with BCR-ABL–positive ALL. Given that approximately 85% of children with BCR-ABL–positive ALL also have a deletion of IKZF1,² two questions with potential clinical and prognostic implications come to mind.

First, could a supervised analysis detect significant differences in the . . . [Full Text of this Article]

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