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Clinical Implications of Basic Research
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Volume 360:2021-2023 May 7, 2009 Number 19
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The Origins of Brown Adipose Tissue
Sven Enerbäck, M.D., Ph.D.

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What is the source of brown adipose tissue? During the formation of the three germ layers (gastrulation), the mesoderm fills the void between the outer shell (ectoderm) and the inner lining (endoderm). From this "filling" develop several specialized cell types, including myocytes, adipocytes, and chondrocytes. A close interrelationship among these cells can be seen when mesoderm-derived cell lines are treated with the modified nucleotide 5-azacytidine, which, when substituted for bona fide cytidine residues, results in demethylated DNA or, rather, in DNA that cannot be methylated. (Methylation of cytidine is commonly seen in regions of the genome that are transcriptionally less . . . [Full Text of this Article]


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From the Sahlgrenska Academy, Institute of Biomedicine, University of Gothenburg, Gothenburg, Sweden.



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