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This Journal feature begins with a case vignette that includes a therapeutic recommendation. A discussion of the clinical problem and the mechanism of benefit of this form of therapy follows. Major clinical studies, the clinical use of this therapy, and potential adverse effects are reviewed. Relevant formal guidelines, if they exist, are presented. The article ends with the author's clinical recommendations.
A 35-year-old man is brought to the emergency department by his wife after ingesting automobile antifreeze in an attempt at self-harm. On presentation, the patient is somnolent. He is afebrile and has a blood pressure of 126/72 mm Hg,
The Clinical Problem
Pathophysiology and Effect of Therapy
Clinical Evidence
Clinical Use
Adverse Effects
Areas of Uncertainty
Guidelines
Recommendations
Source Information
From Toxicology Associates, Denver.
Address reprint requests to Dr. Brent at Toxicology Associates, University of Colorado Health Sciences Center, 2555 S. Downing St., Suite 260, Denver, CO 80210, or at jeffrey.brent@ucdenver.edu.
Related Letters:
Fomepizole for Toxic Alcohol Poisoning
Rehman H., González-Santiago O., Garza-Ocañas L., Brent J.
Extract |
Full Text |
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N Engl J Med 2009;
361:1213-1214, Sep 17, 2009.
Correspondence
This article has been cited by other articles:
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