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Clinical Implications of Basic Research
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Volume 360:2245-2246 May 21, 2009 Number 21
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Common Cold, Uncommon Variation
Gregory A. Poland, M.D., and Michael A. Barry, Ph.D.

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The average person will spend about 5 years suffering from the common cold, and 1 year of that time will be spent with a cold that is severe enough to require bed rest.1 Human rhinovirus (HRV) is responsible for 50 to 80% of common colds and thus causes misery, morbidity, reduced productivity, inappropriate use of antibiotics, and economic costs estimated at more than $60 billion each year in the United States alone.2 Among very young children, older adults, and persons with immunodeficiency, HRV can also cause serious disease of the lower respiratory tract.

HRVs, which were discovered in the 1950s, . . . [Full Text of this Article]


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From the Departments of Medicine (G.A.P., M.A.B.), Immunology (M.A.B.), and Molecular Medicine (M.A.B.) and the Program in Translational Immunovirology and Biodefense (G.A.P., M.A.B.), Mayo Clinic, Rochester, MN.




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