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Previous Volume 360:2247-2248 May 21, 2009 Number 21 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: Sacks et al. (Feb. 26 issue)¹ compare weight-loss diets that vary in macronutrient content, with a targeted maximal difference in the proportion of calories derived from carbohydrates, fat, and protein of 30, 20, and 10 percentage points, respectively. The realized macronutrient differences were substantially smaller than the planned targets, and at 2 years, weight loss was similar in pairwise comparisons of intakes at the high and low extremes of each macronutrient. Neither the targeted nor the actual intakes of carbohydrates or fat in any of the diets would classify them as being substantially low in these macronutrients. . . . [Full Text of this Article]

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