FREE NEJM E-TOC    HOME   |   SUBSCRIBE   |   CURRENT ISSUE   |   PAST ISSUES   |   COLLECTIONS   |   Search Term  Advanced Search

Sign in | Get NEJM's E-Mail Table of Contents — Free | Subscribe

Previous Volume 360:2248-2249 May 21, 2009 Number 21 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

	Full Text PDF PDA Full Text Purchase this article Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited E-mail When Letters Appear Related Article by Yan, H. PubMed Citation

To the Editor: Yan et al. (Feb. 19 issue)¹ found that mutations of genes encoding isocitrate dehydrogenases (IDH1 and IDH2), as compared with no mutations, are associated with younger age and better prognosis in adults with gliomas. Their study and other, similar studies^2,3,4 prompted us to search for mutations at codon 132 of IDH1 in children and adolescents with gliomas. In our series, 155 of 404 adults (38%) and 4 of 73 children (5%) with nonpilocytic gliomas had IDH1 mutations (P<0.001). We did not find IDH2 mutations in tumors in children. We also found that IDH1 mutations in . . . [Full Text of this Article]

HOME  |  SUBSCRIBE  |  SEARCH  |  CURRENT ISSUE  |  PAST ISSUES  |  COLLECTIONS  |  PRIVACY  |  TERMS OF USE  |  HELP  |  beta.nejm.org Comments and questions? Please contact us. The New England Journal of Medicine is owned, published, and copyrighted © 2009 Massachusetts Medical Society. All rights reserved.