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Previous Volume 360:2467-2470 June 4, 2009 Number 23 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

	Full Text PDF PDA Full Text Purchase this article Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited E-mail When Letters Appear Related Article by Lachmann, H. J. Related Article by Aksentijevich, I. Related Article by Reddy, S. PubMed Citation

Interleukin-1 is a highly active proinflammatory cytokine that causes not only fever, anorexia, and other constitutional symptoms but also tissue damage and remodeling. All these effects — including joint destruction, tissue remodeling, and elevated levels of markers of systemic inflammation — can be reversed or reduced by specific blockade of interleukin-1 activity.

Interleukin-1 induces the expression of several other proinflammatory genes, but cytokine-mediated inflammation can also evoke the expression of genes encoding antiinflammatory proteins that nonspecifically suppress inflammation. In the case of interleukin-1, however, a particular molecule that specifically inhibits interleukin-1 activity is induced. The 11 members of the interleukin-1 . . . [Full Text of this Article]

Source Information

From the Division of Infectious Diseases, University of Colorado Denver, Aurora.

This article has been cited by other articles:

• (2009). So, what exactly is a cytokine?. DTB 47: 89-91 [Abstract] [Full Text]  
• (2009). DIRA: A New Autoinflammatory Disease. Journal Watch Dermatology 2009: 1-1 [Full Text]