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Volume 360:2475-2477 June 4, 2009 Number 23
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Behavioral Therapy, Sertraline, or Both in Childhood Anxiety

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 by Emslie, G. J.
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 by Walkup, J. T.
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To the Editor: Walkup and colleagues (Dec. 25 issue)1 conclude that the three active therapies they studied — a combination of cognitive behavioral therapy and sertraline, cognitive behavioral therapy alone, and sertraline alone — were effective treatment for anxiety in children, as compared with placebo. The authors further conclude that combination treatment had a superior response rate, as compared with active treatment alone. However, the study design invites questions. There was no treatment group in which cognitive behavioral therapy plus placebo was used. The absence of such a group prevented the investigators from determining whether the addition of sertraline to . . . [Full Text of this Article]




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