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Volume 360:2575-2576 June 11, 2009 Number 24
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The Precursor of Chronic Lymphocytic Leukemia

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 by Landgren, O.
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To the Editor: Landgren and colleagues (Feb. 12 issue)1 present data that cannot be used to differentiate monoclonal B-cell lymphocytosis (MBL) from chronic lymphocytic leukemia (CLL). The findings of clonal B-cell populations are based on flow-cytometric and molecular analyses, but these approaches do not measure the B-cell count in the prediagnostic blood sample. In Table 2 of the article, the values for "lymphocytes" are percentages of lymphocytes among all cells in the thawed samples measured by means of flow cytometric analysis. Both the absolute lymphocyte count and the percentage of B cells as measured by flow cytometry are mandatory for . . . [Full Text of this Article]




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