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Previous Volume 360:2645-2654 June 18, 2009 Number 25 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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This Journal feature begins with a case vignette that includes a therapeutic recommendation. A discussion of the clinical problem and the mechanism of benefit of this form of therapy follows. Major clinical studies, the clinical use of this therapy, and potential adverse effects are reviewed. Relevant formal guidelines, if they exist, are presented. The article ends with the authors' clinical recommendations.

A previously healthy 59-year-old man presents with persistent pain in his lower back and fatigue. A complete blood count reveals a hemoglobin level of 9.8 g per deciliter. A monoclonal protein (M component) is detected on serum protein electrophoresis . . . [Full Text of this Article]

The Clinical Problem

Pathophysiology and Effect of Therapy

Clinical Evidence

Clinical Use

Adverse Effects

Areas of Uncertainty

Guidelines

Recommendations

Source Information

From the René Gauducheau Cancer Center, Nantes–Saint Herblain (J.-L.H.), and University Hospital Hôtel Dieu, Nantes (P.M.) — both in France.

Address reprint requests to Dr. Harousseau at the René Gauducheau Cancer Center, Blvd. J. Monod, 44805 Nantes–Saint Herblain, France, or at jl-harousseau@nantes.fnclcc.fr.

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Mutation in TET2 in Myeloid Cancers
Tefferi A., Lim K.-H., Levine R., Bernard O. A., Vainchenker W.
Extract | Full Text | PDF  
N Engl J Med 2009; 361:1117-1118, Sep 10, 2009. Correspondence

Autologous Stem-Cell Transplantation for Multiple Myeloma
Louw V. J., Louw H., Webb M. J., Harousseau J.-L., Moreau P.
Extract | Full Text | PDF  
N Engl J Med 2009; 361:1118-1119, Sep 10, 2009. Correspondence

This article has been cited by other articles:

• Leung, A. Y. H., Kwong, Y.-L. (2009). Haematopoietic stem cell transplantation: current concepts and novel therapeutic strategies. Br Med Bull 0: ldp040v1-ldp040 [Abstract] [Full Text]  
• Louw, V. J., Louw, H., Webb, M. J., Harousseau, J.-L., Moreau, P. (2009). Autologous Stem-Cell Transplantation for Multiple Myeloma. NEJM 361: 1118-1119 [Full Text]