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Review Article
Medical Progress
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Volume 360:2758-2769 June 25, 2009 Number 26
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Alcoholic Hepatitis
Michael R. Lucey, M.D., Philippe Mathurin, M.D., Ph.D., and Timothy R. Morgan, M.D.

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Excessive alcohol consumption is the third leading preventable cause of death in the United States.1,2 Alcohol-associated mortality is disproportionately high among young people, and approximately 30 years of life are lost per alcohol-associated death — or, in the aggregate, 2.3 million years of potential life lost in 2001 in the United States.1 Excess consumption of alcohol is associated with both short-term and long-term liver damage, several types of cancer, unintentional injuries both in the workplace and on the road, domestic and social violence, broken marriages, and damaged social and family relationships.3

The association between alcohol intake and alcoholic liver disease . . . [Full Text of this Article]

Clinical Presentation of Alcoholic Hepatitis

Establishing the Diagnosis of Alcoholic Hepatitis

Assessing the Severity of Alcoholic Hepatitis

Mechanisms of Alcohol-Related Liver Injury

Therapy for Alcoholic Hepatitis

Abstinence from Alcohol

Corticosteroids

Pentoxifylline

Anti–TNF-{alpha} Therapy

Nutritional Support

Other Pharmacologic Treatments

Liver Transplantation

Conclusions


Source Information

From the Section of Gastroenterology and Hepatology, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison (M.R.L.); Service des Maladies de l'Appareil Digestif, Hôpital Claude Huriez, INSERM Unité 795, Université Lille 2 (P.M.) — all in Lille, France; and the Gastroenterology Section, Veterans Affairs Long Beach Healthcare System, Long Beach, and the Division of Gastroenterology, University of California, Irvine (T.R.M.) — both in California.

Address reprint requests to Dr. Lucey at the Section of Gastroenterology and Hepatology, H6/516 CSC, University of Wisconsin Hospitals and Clinics, 600 Highland Ave, Madison, WI 53792, or at mrl@medicine.wisc.edu.


Related Letters:

Alcoholic Hepatitis
Mohammed F., Lucey M. R., Mathurin P., Morgan T. R.
Extract | Full Text | PDF  
N Engl J Med 2009; 361:1512-1513, Oct 8, 2009. Correspondence

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