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Volume 360:2784-2786 June 25, 2009 Number 26
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Arrhythmogenic Right Ventricular Cardiomyopathy

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 by Asimaki, A.
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To the Editor: Although the article by Asimaki et al. (March 12 issue)1 is provocative, we remain unconvinced that arrhythmogenic right ventricular cardiomyopathy (ARVC) is caused by a primary defect in the intercalated disk.

No molecular studies reporting desmosomal mutations in autopsy tissues have shown images of morphologic changes indicating ARVC. There is little documentation of pathological features of ARVC in the tissue samples obtained from the subjects in the study by Asimaki et al.

We have been interested in ARVC for many years,2 and we have found no evidence of diffuse connexin 43 abnormalities in patients with ARVC who . . . [Full Text of this Article]




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