The treatment of cancer is generally based on histologic grade,resectability, and the presence or absence of metastasis. Becauseinterventions after the manifestation of metastasis are notoriouslyineffective for most cancers, great effort has been investedin the development of targeted therapies to eradicate or suppressthe growth of micrometastatic disease. In three recent studies,1,2,3investigators implicate potential targets: proteins that mediateboth transformation and metastasis. These studies also providea potential clue to why some cancers have already metastasizedat the time of diagnosis.
The implicated proteins, twist homolog 1 (Twist-1) and two membersof the zinc-finger-protein Snail family, . . . [Full Text of this Article]
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From the Experimental Therapeutics and Translational Oncology Program, Instituto de Biología Molecular y Celular del Cáncer, Consejo Superior de Investigaciones Cientificas–Universidad de Salamanca, Salamanca, Spain.
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