FREE NEJM E-TOC    HOME   |   SUBSCRIBE   |   CURRENT ISSUE   |   PAST ISSUES   |   COLLECTIONS   |   Search Term  Advanced Search

Sign in | Get NEJM's E-Mail Table of Contents — Free | Subscribe

Previous Volume 360:439-443 January 29, 2009 Number 5 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

	Full Text PDF PDA Full Text Slide Presentation Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited E-mail When Letters Appear PubMed Citation

In March 1942, a 33-year-old woman lay dying of streptococcal sepsis in a New Haven, Connecticut, hospital, and despite the best efforts of contemporary medical science, her doctors could not eradicate her bloodstream infection. Then they managed to obtain a small amount of a newly discovered substance called penicillin, which they cautiously injected into her. After repeated doses, her bloodstream was cleared of streptococci, she made a full recovery, and she went on to live to the age of 90.¹ Sixty-six years after her startling recovery, a report² described a 70-year-old man in San Francisco with endocarditis caused by vancomycin-resistant . . . [Full Text of this Article]

Source Information

Dr. Arias is an assistant professor of medicine at the University of Texas Medical School, Houston, and director of the Molecular Genetics and Antimicrobial Resistance Unit, Universidad El Bosque, Bogotá, Colombia. Dr. Murray is a professor and the vice-chair for research in the Department of Internal Medicine and the director of the Division of Infectious Diseases, University of Texas Medical School, Houston.

This article has been cited by other articles:

• Chen, Y.-H., Liu, C.-Y., Lu, J.-J., King, C.-H. R., Hsueh, P.-R. (2009). In vitro activity of nemonoxacin (TG-873870), a novel non-fluorinated quinolone, against clinical isolates of Staphylococcus aureus, enterococci and Streptococcus pneumoniae with various resistance phenotypes in Taiwan. J Antimicrob Chemother 64: 1226-1229 [Abstract] [Full Text]  
• Nakou, A., Woodhead, M., Torres, A. (2009). MRSA as a cause of community-acquired pneumonia. Eur Respir J 34: 1013-1014 [Full Text]  
• Llarrull, L. I., Fisher, J. F., Mobashery, S. (2009). Molecular Basis and Phenotype of Methicillin Resistance in Staphylococcus aureus and Insights into New {beta}-Lactams That Meet the Challenge. Antimicrob. Agents Chemother. 53: 4051-4063 [Full Text]