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A 39-year-old woman in the first trimester of her first pregnancy was seen in the obstetrics and gynecology clinic of this hospital at 14 weeks of gestation because of a recent febrile illness.
She had been well until approximately 9 weeks before this evaluation, when daily fevers with temperatures of up to 38.3°C developed, accompanied by rigors, malaise, myalgias, and fatigue. She took ibuprofen every 6 hours, with some improvement. One week later, she saw her primary care provider.
She reported no headache, stiff neck, nasal congestion, sore throat, cough, nausea, abdominal pain, or diarrhea. Four months before the onset
Differential Diagnosis
Parvovirus Infection
Rubella and Rubeola
Acute Retroviral Illness
Mononucleosis
Toxoplasmosis
CMV Infection
Clinical Diagnosis
Dr. Patrick Duff's Diagnosis
Pathological Discussion
Anatomical Diagnosis
Source Information
From the Department of Obstetrics and Gynecology, University of Florida, Gainesville (P.D.); and the Division of Maternal–Fetal Medicine (W.H.B.) and the Department of Pathology (M.D.P.), Massachusetts General Hospital, and the Departments of Obstetrics, Gynecology, and Reproductive Biology (W.H.B.) and Pathology (M.D.P.), Harvard Medical School — both in Boston.
Related Letters:
Case 4-2009: A Pregnant Woman with Fever after a Trip to Africa
Itskowitz M., Jones J. G., Revello M. G., Duff P., Barth W. H. Jr., Post M. D.
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N Engl J Med 2009;
360:2481-2482, Jun 4, 2009.
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