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Clinical Implications of Basic Research
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Volume 360:532-534 January 29, 2009 Number 5
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Getting to the Heart of Proteomics
Peipei Ping, Ph.D.

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Chen and colleagues1 recently described mitochondrial aldehyde dehydrogenase type 2 (ALDH2) as a target in protecting the heart against ischemic insult. Their study provides insights into cardiovascular biology and may form the basis of a potential therapeutic approach to prevent or minimize myocardial ischemic injury in the clinical setting.

Cardiac cells have innate defense mechanisms against injury that results from prolonged disruption of blood flow as a consequence of a heart attack.2,3,4,5 The presence of these mechanisms was originally revealed with the discovery that brief episodes of ischemia and reperfusion protect the heart against a subsequent prolonged ischemic insult. This . . . [Full Text of this Article]


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From the National Heart, Lung, and Blood Institute Program Project on Myocardial Ischemia Injury and Protection, David Geffen School of Medicine at UCLA, Los Angeles.



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