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Volume 360:535-537 January 29, 2009 Number 5
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Insulin Therapy in Very-Low-Birth-Weight Infants

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by Kashyap, S.
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by Beardsall, K.
-PubMed Citation
To the Editor: Beardsall et al. (Oct. 30 issue)1 report the results of the Neonatal Insulin Replacement Therapy in Europe (NIRTURE) trial, which investigated the effects of a fixed-dose insulin (0.05 U per kilogram of body weight per hour) and glucose (20% dextrose) infusion as compared with usual care in very-low-birth-weight infants in the neonatal intensive care unit (ICU). Beardsall and colleagues, as well as Kashyap and Polin, in their accompanying editorial,2 interpret the negative results of this study as evidence against blood glucose control in premature babies. We do not agree with this interpretation. Pronounced hyperglycemia was present in . . . [Full Text of this Article]



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