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Volume 360:541-542 January 29, 2009 Number 5
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The Statins in Preventive Cardiology

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 by Steinberg, D.
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To the Editor: In his Perspective article, Steinberg (Oct. 2 issue)1 cites the largest meta-analysis to date of the statin class of pharmaceutical agents.2 The range he cites as the relative risk reduction for all-cause mortality, 20 to 30%, is inaccurate. The relative risk reduction was 12% over 5 years. This number means that one death per year was averted for every 417 patients taking a statin drug, or 1 of every 83 patients after 5 years of therapy. The large preponderance of subjects in this meta-analysis had established coronary disease, and the mortality rate among subjects in the control . . . [Full Text of this Article]




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