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Previous Volume 360:542-544 January 29, 2009 Number 5 Next

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To the Editor: Atypical hemolytic–uremic syndrome is a disease of uncontrolled complement activation associated with a high mortality rate, and most cases progress to end-stage renal disease.¹ About 50% of patients with this syndrome carry mutations in genes encoding complement proteins.² Complement inhibition has been suggested for the treatment of atypical hemolytic–uremic syndrome,³ but currently no data on this treatment option are available. We report on a case of atypical hemolytic–uremic syndrome that was successfully treated with eculizumab, a humanized monoclonal antibody that blocks complement activity by cleavage of the complement protein C5, thereby preventing the generation of the inflammatory . . . [Full Text of this Article]

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