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Previous Volume 360:550-551 January 29, 2009 Number 5

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(Infectious Disease and Therapy. 48.) Edited by Robert C. Owens, Jr., and Ebbing Lautenbach. 492 pp., illustrated. New York, Informa Healthcare, 2008. $299.95. ISBN 978-0-8247-2941-7.

The antimicrobial era began about 75 years ago. Although it is far from over, it is being increasingly challenged by the emergence of resistant microorganisms. Antimicrobial resistance is the inevitable result of Darwinian evolution — natural selection and survival of the fittest. The emergence of resistance has been accelerated by the excessive use of antibiotics in conjunction with the remarkable genetic plasticity of microorganisms.

There is a close association between nosocomial infections and antibiotic use. Antimicrobial drugs can be helpful in the management of infectious complications of invasive procedures, immunosuppression, and aging, but they can have adverse side effects and . . . [Full Text of this Article]

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