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Volume 360:634-636 February 5, 2009 Number 6
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Toll-like Receptor 4 Polymorphisms and Aspergillosis

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 by Bochud, P.-Y.
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To the Editor: Bochud et al. (Oct. 23 issue)1 present data suggesting an association between toll-like receptor 4 (TLR4) haplotypes in unrelated donors and an increased risk of invasive aspergillosis among recipients of allogeneic hematopoietic-cell transplants. The authors theorize that this association is due to the capacity of TLR4 to recognize ligands present on Aspergillus fumigatus.2 However, there is another possible explanation for the findings that should be considered. During much of the period of the study, transplant recipients with febrile neutropenia that was unresponsive to antibiotics received amphotericin B. This is significant because conventional and lipid . . . [Full Text of this Article]




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