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Previous Volume 360:925-927 February 26, 2009 Number 9 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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It has been known for decades that the Y chromosome carries genes required for spermatogenesis and male fertility. But it has been frustratingly difficult to pin down the relevant genes, to such an extent that a finding reported by Luddi et al.¹ in this issue of the Journal — that the ubiquitin-specific peptidase 9, Y-linked gene (USP9Y) is not essential for normal spermatogenesis — represents a noteworthy advance in the field.

Approximately 15% of couples have difficulty conceiving; the causes are many and include genetic factors. The most common known genetic causes of spermatogenic failure are karyotype anomalies . . . [Full Text of this Article]

Source Information

From the Wellcome Trust Sanger Institute, Hinxton, United Kingdom (C.T.-S.); and the Andrology Unit, Department of Clinical Physiopathology, University of Florence, Florence, Italy (C.K.).

This article has been cited by other articles:

• Giachini, C., Nuti, F., Turner, D. J., Laface, I., Xue, Y., Daguin, F., Forti, G., Tyler-Smith, C., Krausz, C. (2009). TSPY1 Copy Number Variation Influences Spermatogenesis and Shows Differences among Y Lineages. J. Clin. Endocrinol. Metab. 94: 4016-4022 [Abstract] [Full Text]