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Volume 361:1117-1118 September 10, 2009 Number 11
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Mutation in TET2 in Myeloid Cancers

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by Delhommeau, F.
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To the Editor: The finding of Delhommeau and colleagues that TET2 mutations occur in myeloid cancers (May 28 issue)1 has been confirmed by others.2,3,4,5 The presence of single-copy and double-copy TET2 defects and the frequent occurrence of frameshift, nonsense, or deletion mutations are consistent with the notion that TET2 is a tumor suppressor. Delhommeau et al. suggest a role for TET2 in disease progression. We looked into this possibility by studying stored, serial bone marrow samples from eight patients with myeloproliferative neoplasms. Mutant TET2 was not detected in any of the follow-up samples, even though leukemic or fibrotic transformation occurred . . . [Full Text of this Article]



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