FREE NEJM E-TOC    HOME   |   SUBSCRIBE   |   CURRENT ISSUE   |   PAST ISSUES   |   COLLECTIONS   |   Search Term  Advanced Search

Sign in | Get NEJM's E-Mail Table of Contents — Free | Subscribe

Previous Volume 361:1118 September 10, 2009 Number 11 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

	Full Text PDF PDA Full Text Purchase this article Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited E-mail When Letters Appear Related Article by Savva, G. M. PubMed Citation

To the Editor: Savva et al. (May 28 issue)¹ reported on the assessment of the pathologic features of 456 brains donated from older old persons with or without dementia. Although their results challenge the current idea that neuritic plaques and tangles are a hallmark of Alzheimer's disease in a younger old cohort, the results should still merit reexamining the detailed mechanisms of how these pathologic factors induce neuronal loss or dementia. Furthermore, it is essential to incorporate neuronal and synaptic loss into a quantitative evaluation of pathologic changes in both younger and older cohorts of persons with dementia; pathologic changes . . . [Full Text of this Article]

HOME  |  SUBSCRIBE  |  SEARCH  |  CURRENT ISSUE  |  PAST ISSUES  |  COLLECTIONS  |  PRIVACY  |  TERMS OF USE  |  HELP  |  beta.nejm.org Comments and questions? Please contact us. The New England Journal of Medicine is owned, published, and copyrighted © 2009 Massachusetts Medical Society. All rights reserved.