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Volume 361:1212-1213 September 17, 2009 Number 12
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Duration of Androgen Suppression in Prostate Cancer

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 by Bolla, M.
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To the Editor: In the trial conducted by Bolla et al. (June 11 issue),1 more than 70% of the patients had clinical T3 disease, and the median level of prostate-specific antigen (PSA) in patients who underwent randomization was 18.8 ng per milliliter, with a range of up to 159.2. Furthermore, about 20% of the patients presented with Gleason scores of 5 or less, suggesting that these tumors were downgraded as compared with current trends in diagnosis.2 Since bone scans were not mandated as part of the study, a clinically significant number of patients were likely to have had metastatic disease . . . [Full Text of this Article]




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