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Previous Volume 361:1307-1309 September 24, 2009 Number 13 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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The cytokine interferon- is thought to exert its antitumor effects through pleiotropic mechanisms, including the modulation of immune responses and the inhibition of angiogenesis.¹ In addition, interferon- inhibits growth and promotes apoptosis of many cell types. A recent study by Essers and colleagues² provides new insight into the effects of interferon- on hematopoietic stem cells, revealing its proliferative effects on this quiescent cell population. Their findings also suggest a potential therapeutic application of interferons in shifting dormant yet viable cancer cells into the cell cycle to increase their susceptibility to cytotoxic chemotherapy.

The essential quality of a benign stem cell . . . [Full Text of this Article]

Source Information

From the Section of Hematology/Oncology, Department of Medicine, University of Chicago, Chicago.

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