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Background It is unclear whether functional status before dialysis is maintained after the initiation of this therapy in elderly patients with end-stage renal disease (ESRD).
Methods Using a national registry of patients undergoing dialysis, which was linked to a national registry of nursing home residents, we identified all 3702 nursing home residents in the United States who were starting treatment with dialysis between June 1998 and October 2000 and for whom at least one measurement of functional status was available before the initiation of dialysis. Functional status was measured by assessing the degree of dependence in seven activities of daily living (on the Minimum Data Set–Activities of Daily Living [MDS–ADL] scale of 0 to 28 points, with higher scores indicating greater functional difficulty).
Results The median MDS–ADL score increased from 12 during the 3 months before the initiation of dialysis to 16 during the 3 months after the initiation of dialysis. Three months after the initiation of dialysis, functional status had been maintained in 39% of nursing home residents, but by 12 months after the initiation of dialysis, 58% had died and predialysis functional status had been maintained in only 13%. In a random-effects model, the initiation of dialysis was associated with a sharp decline in functional status, indicated by an increase of 2.8 points in the MDS–ADL score (95% confidence interval [CI], 2.5 to 3.0); this decline was independent of age, sex, race, and functional-status trajectory before the initiation of dialysis. The decline in functional status associated with the initiation of dialysis remained substantial (1.7 points; 95% CI, 1.4 to 2.1), even after adjustment for the presence or absence of an accelerated functional decline during the 3-month period before the initiation of dialysis.
Conclusions Among nursing home residents with ESRD, the initiation of dialysis is associated with a substantial and sustained decline in functional status.
Source Information
From the Division of Nephrology, Department of Medicine, Stanford University School of Medicine, Palo Alto, CA (M.K.T., G.M.C.); and the Division of Geriatrics, Department of Medicine (K.E.C., C.S.L.), the Departments of Psychiatry and Neurology (K.Y.) and Epidemiology and Biostatistics (K.Y., C.E.M.), University of California San Francisco; and the San Francisco VA Medical Center (K.E.C., K.Y., C.S.L.) — both in San Francisco.
Address reprint requests to Dr. Kurella Tamura at the Division of Nephrology, Stanford University School of Medicine, 780 Welch Rd., Suite 106, Palo Alto, CA 94304, or at mktamura{at}stanford.edu.
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