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Clinical Implications of Basic Research
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Volume 361:1704-1706 October 22, 2009 Number 17
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The Index Lesion and the Origin of Prostate Cancer
Hashim Uddin Ahmed, M.R.C.S., B.M., B.Ch.

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Prostate cancer is a perplexing type of malignant disease. Its long natural history means that men who receive the diagnosis in their 50s or 60s do not necessarily require treatment. Most of these men neither die prematurely nor have a reduced quality of life if the cancer is left untreated. The problem is that there is no definitive way to identify those who will die from the disease. Efforts have thus been focused on reducing the considerable burden imposed by complications related to treatment.

The use of formal and informal screening has led to a dramatic increase in the number . . . [Full Text of this Article]


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From the Division of Surgery and Interventional Sciences, University College; and the National Institute for Health Research–Comprehensive Biomedical Research Centre, University College Hospital — both in London.




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