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This Journal feature begins with a case vignette that includes a therapeutic recommendation. A discussion of the clinical problem and the mechanism of benefit of this form of therapy follows. Major clinical studies, the clinical use of this therapy, and potential adverse effects are reviewed. Relevant formal guidelines, if they exist, are presented. The article ends with the author's clinical recommendations.
A sexually active 18-year-old woman presents to her internist for an annual examination. During the review of her family history, she notes that her mother recently received a diagnosis of "pre–cervical cancer" and underwent a loop electrosurgical excision procedure.
The Clinical Problem
Pathophysiological Features and Effect of Therapy
Clinical Evidence
Clinical Use
Adverse Effects
Areas of Uncertainty
Guidelines
Recommendations
Source Information
From the Division of Adolescent Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati.
Address reprint requests to Dr. Kahn at the Division of Adolescent Medicine, MLC 4000, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave., Cincinnati, OH 45229, or at jessica.kahn@cchmc.org.
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N Engl J Med 2009;
361:1610-1611, Oct 15, 2009.
Correspondence
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