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Volume 361:307-308 July 16, 2009 Number 3
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Male Circumcision for the Prevention of HSV-2 and HPV Infections

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by Tobian, A. A.R.
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To the Editor: When Tobian et al. (March 26 issue)1 sampled only the glans for human papillomavirus (HPV), they guaranteed a positive finding because the location of HPV on the penis differs according to circumcision status.2,3,4,5 Uncircumcised men with HPV have the virus on the glans 65% of the time, whereas circumcised men with HPV have the virus on the glans 48% of the time.2 Consequently, sampling only the glans will underestimate the risk of HPV among circumcised men by about 35%. If the numbers reported in the study by Tobian and colleagues are adjusted for this sampling bias, the . . . [Full Text of this Article]



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