It is increasingly clear that neoplastic cells and the immunesystem are locked in a struggle in which each attempts to outmaneuverits opponent. One tactic that tumors use to avoid attack byT cells and natural killer cells is the suppression of immune-recognitionmolecules.1 Evasion by this means is possible when cancer cellslose an HLA haplotype that was inherited from one of the patient'sparents and replace it with a haplotype from the other parent(Figure 1). The loss occurs during mitotic recombination, leavingthe daughter cell with two HLA haplotypes derived from onlyone parent . . . [Full Text of this Article]
Source Information
From the National Heart, Lung, and Blood Institute, Bethesda, MD (J.B.); and the University of Minnesota, Minneapolis (B.R.B.).
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