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Volume 361:535-536 July 30, 2009 Number 5
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Asthma in Pregnancy

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by Schatz, M.
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To the Editor: In their review article on asthma in pregnancy (April 30 issue),1 Schatz and Dombrowski state that leukotriene-receptor antagonists may be considered as an alternative to inhaled corticosteroids in pregnancy. However, current guidelines by the British Thoracic Society2 advocate against starting these agents during pregnancy. Given the limited safety data available on leukotriene-receptor antagonists and the literature regarding the safety of inhaled corticosteroids during pregnancy,3,4 use of the corticosteroids would seem a better approach in cases of mild asthma.


Stuart Schembri, M.D.
Perth Royal Infirmary
Perth PH1 1NX, United Kingdom
sschembri@nhs.net

  1. Schatz M, Dombrowski M. Asthma in pregnancy. N Engl J Med 2009;360:1862-1869. [Free Full Text]
  2. British Thoracic Society Scottish Intercollegiate Guidelines Network. British Guideline on the Management of Asthma. Thorax 2008;63:Suppl 4:iv1-iv121. [Free Full Text]
  3. Schatz M, Zeiger RS, Harden K, Hoffman CC, Chilingar L, Petitti D. The safety of asthma and allergy medications during pregnancy. J Allergy Clin Immunol 1997;100:301-306. [CrossRef][Web of Science][Medline]
  4. Dombrowski M, Thom E, McNellis D. Maternal-Fetal Medicine Units (MFMU) studies of inhaled corticosteroids during pregnancy. J Allergy Clin Immunol 1999;103:S356-S359. [CrossRef][Web of Science][Medline]
 
The authors reply: We agree that inhaled . . . [Full Text of this Article]



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