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Volume 361:822-824 August 20, 2009 Number 8
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Early versus Deferred Antiretroviral Therapy for HIV

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by Sax, P. E.
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by Kitahata, M. M.
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To the Editor: Kitahata et al. (April 30 issue)1 addressed the question of whether persons who received antiretroviral therapy during their study lived longer if that treatment was initiated early rather than deferred. Through careful selection and censoring of patients in various subgroups, the authors attempted to eliminate a variety of sources of bias.

However, in censoring patients who did not start antiretroviral therapy during follow-up, they have selectively eliminated from the deferred-therapy group, but not the early-therapy group, those patients in whom disease progression was relatively slow. This introduces potential bias when addressing the related question of when to . . . [Full Text of this Article]



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