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Clinical Implications of Basic Research
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Volume 361:922-924 August 27, 2009 Number 9
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Finding the Weakness in Cancer
Julian Downward, Ph.D.

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By the time the sequencing of the human genome was completed 6 years ago, expectations were huge that this knowledge would soon have an impact on our ability to treat disease, nowhere more so than in oncology. The genome sequence itself amounted to no more than a parts list, with minimal clues to function. Fortunately, however, at about the same time a powerful technology for rapidly probing the biologic roles of genes became available in the form of RNA interference. The coming together of these two breakthroughs, which make up part of what is often referred to as "functional genomics," . . . [Full Text of this Article]


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From the Cancer Research UK London Research Institute, London.




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