Percutaneous transluminal coronary angioplasty has become themost frequently used method for myocardial revascularization.1The use of uncoated coronary-artery stents during percutaneousintervention has decreased the incidence of acute complicationsand improved the outcome of patients,2 but restenosis withinthe stent compromises the long-term results. As a consequence,the prevention and treatment of in-stent restenosis have becomepriorities in interventional cardiology.
Drug-eluting stents, which markedly reduce in-stent restenosis,3have relegated all other therapeutic approaches to the background.However, it is gradually emerging that rates of late restenosisafter the use of drug-eluting stents are higher than initialexperience suggested, particularly . . . [Full Text of this Article]
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From the Cardiology Department, University Hospital, Geneva.
This article was published at www.nejm.org on November 13, 2006.
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