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Published at www.nejm.org September 17, 2007 (10.1056/NEJMe078192)

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More than 300,000 hip fractures occur annually in the United States,¹ the majority related to osteoporosis and falls in older people. Not surprisingly, the public health implications and economic burden associated with this condition are enormous.^2,3 In patients who have sustained a hip fracture, a 2-year mortality rate of 36% has been observed.⁴ Many of those who survive do not regain their prefracture level of mobility⁵ and thereby endure loss of independence and deterioration in health-related quality of life. Persons who fracture a hip are 2.5 times as likely to have a subsequent skeletal fracture as are those without a . . . [Full Text of this Article]

Source Information

From the Department of Pharmacy, Mark O. Hatfield Clinical Research Center, National Institutes of Health, Bethesda (K.A.C., F.P.); the Department of Pharmacy Practice and Science, School of Pharmacy, University of Maryland, Baltimore (K.A.C.); and the Endocrinology Expert Committee, United States Pharmacopeia, Rockville (K.A.C., F.P.) — all in Maryland.

This article (10.1056/NEJMe078192) was published at www.nejm.org on September 17, 2007. It will appear in the November 1 issue of the Journal.

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