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Published at www.nejm.org September 21, 2007 (10.1056/NEJMe078196)

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The normalization of glucose levels plays an important role in protecting patients with diabetes from complications such as myocardial infarction and stroke. To accomplish this goal, most patients with type 2 diabetes will ultimately require treatment with insulin, since oral antidiabetic drugs become insufficient as insulin production declines. Many diabetologists recommend that insulin therapy be initiated if a patient has a glycated hemoglobin level of more than 7% after having received the maximal dose of two oral agents for more than a few months.¹

The question of how to initiate insulin therapy in patients with type 2 diabetes has become . . . [Full Text of this Article]

Source Information

Drs. McMahon and Dluhy are editors at the Journal.

This article (10.1056/NEJMe078196) was published at www.nejm.org on September 21, 2007. It will appear in the October 25 issue of the Journal.

This article has been cited by other articles:

• Dagdelen, S., Ilag, L. L., Martin, S., Jacober, S. J., Holman, R. R., Farmer, A. J., Davies, M. J., McMahon, G. T., Dluhy, R. G. (2008). Addition of insulin to oral therapy in type 2 diabetes.. NEJM 358: 1197-1198 [Full Text]  
• Riddle, M. C. (2008). Starting and Advancing Insulin for Type 2 Diabetes: Algorithms and Individualized Methods Are Both Necessary. J. Clin. Endocrinol. Metab. 93: 372-374 [Full Text]