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Published at www.nejm.org March 16, 2008 (10.1056/NEJMe0800524)

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The role of eosinophils in common diseases — such as asthma, parasitic disease, or allergic reactions — remains speculative. Even more puzzling is the eclectic group of rare disorders that constitute the hypereosinophilic syndromes. These syndromes are characterized by persistently high levels of blood eosinophils and their toxic mediators (e.g., eosinophilic cationic protein and eosinophil-derived neurotoxin), accompanied by severe multiorgan damage.¹ The hypereosinophilic syndromes exclude secondary causes of eosinophilia such as infection while including myeloproliferative and lymphoproliferative variants, associated eosinophilic conditions that fulfill specific diagnostic criteria (e.g., the Churg–Strauss syndrome and mastocytosis), and the complex, undefined conditions affecting a large . . . [Full Text of this Article]

Source Information

From Harvard Medical School and Brigham and Women's Hospital — both in Boston.

This article (10.1056/NEJMe0800524) was published at www.nejm.org on March 16, 2008. It will appear in the March 20 issue of the Journal.

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